- Jefferson City, state capital of Missouri
- Boonville, starting point of the Santa Fe Trail
- Clinton, the starting point of the Katy Trail
- Columbia, home of the University of Missouri - Columbia
- Rolla, home of the University of Missouri - Rolla
- St. Robert
The Santa Fe Trail originates in this region.
This page was last edited at 21:44, on 27 September 2007 by Wikitravel user Jykcjy. Based on work by Stacy Hall, Tom Holland, Bill Johnson and Tom Carver and Anonymous user(s) of Wikitravel.